A Cross-sectional Study of Antipsychotic
Drugs Induced Sexual Dysfunction
among Married Males with Remitted
Schizophrenia Attending Tertiary Health
Care Centre from Central India
Published: March 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/46625.14608
Rameez Abdul Karim Shaikh, Ajinkya Sureshrao Ghogare, Parul Prasad, Shrikant Deshmukh
1. Senior Resident, Department of Psychiatry, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, Maharashtra, India.
2. Assistant Professor, Department of Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi,
Maharashtra, India.
3. Assistant Professor, Department of Psychiatry, Career Institute of Medical Sciences and Hospital, Lucknow, Uttar Pradesh, India.
4. Ex. Professor and Head, Department of Psychiatry, Dr Panjabrao alias Bhausaheb Deshmukh Memorial Medical College, Amravati, Maharashtra, India.
Correspondence
Dr. Ajinkya Sureshrao Ghogare,
Assistant Professor, Department of Psychiatry, Jawaharlal Nehru Medical College,
Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi,
Wardha-442001, Maharashtra, India.
E-mail: ajinkyaghogaremd@gmail.com
Introduction: Schizophrenia is a chronic debilitating disease having a major impact on the sufferers’ lives. Antipsychotic drugs are the mainstay of the treatment of schizophrenia. But, antipsychotics can lead to a variety of sexual dysfunctions among the males with schizophrenia, which may affect their treatment compliance.
Aim: To assess the prevalence and the types of sexual dysfunctions among married males with remitted schizophrenia who were on a single oral antipsychotic drug from either class (i.e., typical or atypical type).
Materials and Methods: The present cross-sectional study was conducted in a tertiary health-care centre from Central India, with a sample size of 100 married males with schizophrenia who were in the remission phase on a single oral antipsychotic drug. Data were collected by using a convenient sampling method. Socio-demographic profile and clinical variables were recorded in a specific case report form prepared for the study using the Arizona Sexual Experiences (ASEX) scale and the Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale to assess the prevalence and the types of oral antipsychotic drugs induced sexual dysfunctions among study participants.
Results: The prevalence of antipsychotic drug induced sexual dysfunction was 54%. The most common type of sexual sideeffect of oral antipsychotic treatment was Decreased Sexual Desire/Drive (DSD) as assessed by both ASEX (94.4%) and UKU (63.0%) scales. Sexual dysfunctions like DSD and Ejaculatory Dysfunction (EJD) were associated with the treatment of schizophrenia with typical antipsychotic drugs.
Conclusion: The present study shows that the treatment with typical antipsychotics was significantly associated with sexual side-effects. So, routine inquiry during the follow-ups should be done regarding the evaluation of sexual side-effects of antipsychotic agents in order to improve treatment compliance and disease prognosis.
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